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Updated: Aug 30, 2025

Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors
Published on: February 16, 2024
Esophageal Schwannoma: An Important Differential Diagnosis for Esophageal Subepithelial Lesions
Bola Nashed1, Mohamad F Ayas1, Hussein Gharib1
1Internal Medicine, Ascension St. John Hospital, Detroit, USA.
Abstract:
Esophageal schwannoma is a rare tumor and is classified as one of the esophageal subepithelial lesions (SELs). Endoscopic ultrasound (EUS) evaluation is the gold standard for evaluating subepithelial lesions. Differentiation through EUS-guided fine needle aspiration is sometimes important to exclude lesions with malignant potential. Immunohistochemistry differentiates schwannoma from other subepithelial lesions. Strong and diffuse positivity for S100 is characteristic. The decision for conservative management versus endoscopic or thoracoscopic intervention is made based on the tumor size, location, and symptoms.
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