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Analyses of Ocular Adverse Reactions Associated With Anticancer Drugs Based on the Japanese Pharmacovigilance

Junko Tanaka1, Takenao Koseki2, Masashi Kondo3

  • 1Department of Clinical Pharmacy, Fujita Health University School of Medicine, Toyoake, Japan.

Anticancer Research
|August 30, 2022
PubMed
Abstract

Insights

Systemic anticancer drugs can cause ocular adverse reactions (OARs), though their frequency is often unknown. This study identified safety signals for various OARs linked to specific anticancer drugs using a Japanese pharmacovigilance database.

Area of Science:

  • Ophthalmology
  • Pharmacovigilance
  • Oncology

Background:

  • Systemic anticancer drugs can lead to ocular adverse reactions (OARs).
  • The frequency and specific drug associations of these OARs are not well-established.
  • A comprehensive analysis of OARs associated with anticancer drugs is needed.

Purpose of the Study:

  • To investigate the occurrence of OARs induced by systemic anticancer drugs.
  • To identify specific anticancer drugs associated with various OARs.
  • To utilize a large spontaneous pharmacovigilance database for signal detection.

Main Methods:

  • Analysis of the Japanese Adverse Drug Event Report (JADER) database.
  • Evaluation of safety signals for eight types of OARs.
  • Calculation of reporting odds ratios (RORs) and information components (ICs) to assess drug-event associations.

Main Results:

  • Safety signals were detected for multiple OARs linked to specific anticancer drugs, including imatinib, lapatinib, S-1, erlotinib, capecitabine, cetuximab, gefitinib, vandetanib, trastuzumab emtansine, pembrolizumab, lenalidomide, pomalidomide, elotuzumab, tamoxifen, bexarotene, venetoclax, encorafenib, binimetinib, nab-paclitaxel, trametinib, dabrafenib, and blinatumomab.
  • Specific associations included corneal disorders with several drugs, lens disorders with lenalidomide and others, and retinal disorders with tamoxifen and others.
  • Differences in safety signals were observed based on patient sex and age for some drug-OAR combinations.

Conclusions:

  • Several anticancer drugs show safety signals for OARs, including previously unreported events.
  • These findings aid oncologists, ophthalmologists, and pharmacists in predicting and managing OARs.
  • Enhanced awareness of these drug-induced OARs is crucial for patient safety.
Keywords:
Anticancer drugJADERJapanese Adverse Drug Event Reportocular adverse reactionspharmacovigilance databasesafety signal

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