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Updated: Aug 30, 2025

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
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Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting

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Risk factors associated with nausea and vomiting in children with cancer receiving chemotherapy

Astrid Eliasen1,2,3, J Kornholt1,3, R Mathiasen2

  • 1Department of Clinical Pharmacology, Bispebjerg and Frederiksberg University Hospital, Copenhagen, Denmark.

Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners
|August 30, 2022
PubMed

Insights

Children’s susceptibility to motion sickness and older age increase acute chemotherapy-induced nausea (CIN) risk. Controlling acute nausea is vital for preventing delayed CIN in pediatric cancer patients.

Area of Science:

  • Pediatric Oncology
  • Clinical Pharmacology
  • Cancer Symptom Management

Background:

  • Chemotherapy-induced nausea (CIN) is a significant challenge in pediatric cancer care, often inadequately controlled by antiemetics.
  • Risk factors for CIN in children are not well understood, necessitating further research.

Purpose of the Study:

  • To identify specific risk factors associated with chemotherapy-induced nausea in pediatric cancer patients.

Main Methods:

  • A prospective, observational study was conducted with 101 children undergoing moderately or highly emetogenic chemotherapy.
  • Data collected included patient demographics, cancer type, susceptibility to motion sickness, antiemetic use, and prior nausea/vomiting history.
  • Multivariable analyses assessed factors influencing complete control of acute (0-24h) and delayed (24h-5 days) CIN.

Main Results:

  • Acute CIN risk was significantly higher in children with a susceptibility to motion sickness (OR 5.73) and older children (8-18 years vs 0-3 years, OR 4.19).
  • Delayed CIN was strongly associated with uncontrolled acute nausea/vomiting (OR 10.3), highly emetogenic chemotherapy (OR 8.26), and hematologic cancer types (OR 7.81).

Conclusions:

  • Susceptibility to motion sickness and patient age are key predictors of acute CIN in children.
  • Effective management of acute nausea and vomiting is critical to prevent the development of delayed CIN.
  • Further research is warranted to integrate these risk factors into optimized antiemetic strategies for pediatric cancer patients.
Abstract

Keywords:
Chemotherapy-induced nauseamobile healthnauseapaediatricsrisk factors

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