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Progress in the effect of microRNA-21 on diseases via autophagy

Zhengpeng Zeng1,2, Jinwen Cai3, Yumei Liao3

  • 1Center of Health Management, Third Xiangya Hospital, Central South University, Changsha 410013. 974115114@qq.com.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
|August 30, 2022
PubMed

Insights

Autophagy, a cellular recycling process crucial for homeostasis, is regulated by microRNAs (miRNAs). MiRNA-21 influences autophagy, impacting diseases like cancer and injury.

Area of Science:

  • Cellular biology
  • Molecular mechanisms of autophagy
  • MicroRNA regulation

Background:

  • Autophagy is a fundamental cellular process for degrading damaged components and maintaining homeostasis.
  • MicroRNAs (miRNAs) have emerged as key regulators in various biological processes, including autophagy.
  • Dysregulation of autophagy is implicated in numerous diseases.

Purpose of the Study:

  • To explore the intricate relationship between microRNA-21 (miRNA-21) and autophagy.
  • To elucidate the role of miRNA-21 in modulating autophagy pathways.
  • To understand the implications of miRNA-21-mediated autophagy in disease pathogenesis.

Main Methods:

  • Review of existing literature on autophagy and miRNA regulation.
  • Analysis of studies investigating miRNA-21's targets and pathways.
  • Correlation of miRNA-21's effect on autophagy with disease outcomes.

Main Results:

  • MiRNA-21 exhibits a dual role, promoting or inhibiting autophagy depending on the cellular context and target genes.
  • MiRNA-21 regulates key proteins and signaling pathways involved in autophagic flux.
  • Aberrant miRNA-21 levels are associated with the progression of tumors and ischemia-reperfusion injury.

Conclusions:

  • MiRNA-21 is a significant modulator of autophagy with implications for cellular health and disease.
  • Targeting the miRNA-21-autophagy axis presents potential therapeutic strategies for various pathologies.
  • Further research is warranted to fully unravel the complex interplay between miRNA-21 and autophagy in different disease models.
Keywords:
autophagyischemia-reperfusion injurymicroRNA-21tumor

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