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Herpes zoster in patients with lung cancer treated with PD-1/PD-L1 antibodies
Yoshiaki Nagai1, Masafumi Sata1, Hiromitsu Ohta2
1Division of Respiratory Medicine, Department of Internal Medicine, Jichi Medical University Hospital, 3311-1 Yakushi-ji, Shimotsuke-shi, Tochigi-ken, 329-0431, Japan.
Abstract:
Background: There are no available clinical data on immunotherapy and the risk of herpes zoster. Materials & methods: This retrospective study included patients with recurrent or advanced lung cancer who were inoperable and ineligible for radiotherapy and were treated with either a PD-1/PD-L1 antibody (136 patients) or an EGFR tyrosine kinase inhibitor (149 patients) at Jichi Medical University Hospital between January 2016 and December 2018. Results: Herpes zoster-free survival was significantly shorter in the PD-1/PD-L1 antibody-treated group compared with the EGFR tyrosine kinase inhibitor-treated group (hazard ratio: 0.20; 95% CI: 0.048-0.84; p = 0.016). PD-1/PD-L1 antibody administration was independently and significantly associated with herpes zoster occurrence. Conclusion: Clinicians should anticipate herpes zoster in patients with lung cancer during treatment with PD-1/PD-L1 antibodies.
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