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    Area of Science:

    • Endocrinology
    • Psychiatry

    Background:

    • Both Cushing's syndrome and pseudo-Cushing's syndrome involve hypercortisolism.
    • Cushing's syndrome results from corticosteroid administration or cortisol overproduction by tumors.
    • Pseudo-Cushing's syndrome involves HPA-axis hyperactivity, often linked to depression.

    Purpose of the Study:

    • To highlight the diagnostic challenges posed by cyclic Cushing's syndrome.
    • To emphasize the importance of considering cyclic Cushing's syndrome in specific clinical scenarios.

    Main Methods:

    • This abstract discusses the clinical presentation and diagnostic considerations for cyclic Cushing's syndrome.
    • It reviews the differential diagnosis between Cushing's syndrome, pseudo-Cushing's syndrome, and cyclic variants.

    Main Results:

    • Cyclic Cushing's syndrome is characterized by intermittent hypercortisolism.
    • This condition can mimic or complicate the diagnosis of depression.
    • Persistent or extreme hypercortisolism, especially with tumor suspicion, warrants consideration of cyclic Cushing's syndrome.

    Conclusions:

    • Cyclic Cushing's syndrome requires consideration in patients with depression, particularly those with atypical features or treatment resistance.
    • Early recognition and diagnosis are crucial for appropriate management.
    • Distinguishing cyclic Cushing's from other forms of hypercortisolism is essential for patient care.