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Updated: Aug 30, 2025

Gene Transfer for Ischemic Heart Failure in a Preclinical Model
Published on: May 15, 2011
Endocardial Gene Delivery Using NOGA Catheter System
Satu Siimes1, Niko Järveläinen1, Henna Korpela1
1A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Abstract:
NOGA/MyoStar system uses low magnetic fields and endomyocardial electrical parameters, allowing precise endomyocardial injections of therapeutic agents to ischemic yet viable myocardium which is most likely to respond to the treatment. Preclinical and clinical studies have shown that NOGA/MyoStar guided intramyocardial injections are safe, feasible and a minimally invasive way to deliver gene therapy to the heart. Here we describe how to perform electroanatomical mapping and injections to hibernating myocardium in the preclinical studies.
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