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Updated: Aug 30, 2025

Delivery of Modified mRNA in a Myocardial Infarction Mouse Model
Published on: June 11, 2020
[Myocarditis following mRNA vaccine]
Anna Formanek1, Thomas Wagner2, Stephan Newrkla3
1Department of Paediatrics and Youth Medicine, Clinic Donaustadt, Langobardenstr. 122, 1220, Wien, Österreich. anna.formanek@gesundheitsverbund.at.
A 15-year-old experienced myocarditis after the second dose of the BNT162b2 mRNA vaccine (Comirnaty®). Symptoms resolved quickly with rest and symptomatic treatment, indicating a mild course.
Area of Science:
- Cardiology
- Vaccinology
- Pediatric Medicine
Context:
- Myocarditis is a rare but serious condition affecting the heart muscle.
- The BNT162b2 mRNA vaccine (Comirnaty®) is widely used for COVID-19 prevention.
- Adolescents represent a key demographic for vaccination campaigns.
Purpose:
- To report a case of myocarditis in an adolescent following BNT162b2 mRNA vaccination.
- To describe the clinical presentation, diagnostic findings, and outcome of this case.
Summary:
- A 15-year-old presented with chest pain four days post-BNT162b2 mRNA vaccination.
- Elevated Troponin-I and cardiac MRI findings confirmed myocarditis.
- The patient experienced a mild course with rapid symptom resolution after symptomatic therapy and bed rest.
Impact:
- This case contributes to understanding the potential cardiac side effects of mRNA vaccines in adolescents.
- Highlights the importance of considering vaccine-associated myocarditis in adolescents presenting with chest pain post-vaccination.
- Emphasizes the generally favorable prognosis with prompt diagnosis and management.
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