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In-Hospital Hyperglycemia Is Associated With Worse Outcomes in Patients Admitted With COVID-19

Angela Lombardi1, Shivani Agarwal1, Clyde Schechter2

  • 1Einstein-Mount Sinai Diabetes Research Center, The Norman Fleischer Institute for Diabetes and Metabolism, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY.

Diabetes Care
|August 30, 2022
PubMed

Insights

Hyperglycemia in diabetic patients hospitalized with COVID-19 significantly increases mortality and the need for mechanical ventilation. Tight inpatient glycemic control may improve outcomes for these high-risk patients.

Area of Science:

  • Internal Medicine
  • Endocrinology
  • Infectious Diseases

Background:

  • Diabetes and outpatient glycemic control are known risk factors for sepsis complications.
  • The impact of inpatient glycemic control on COVID-19 outcomes in diabetic patients remains unclear.

Purpose of the Study:

  • To investigate the effect of inpatient hyperglycemia on outcomes in diabetic patients hospitalized with COVID-19.

Main Methods:

  • Analysis of 1,938 diabetic COVID-19 patients from March-May 2020.
  • Categorization into normoglycemic and hyperglycemic groups.
  • Cox proportional hazards regression to assess mortality and mechanical ventilation risk.

Main Results:

  • 68% of patients were hyperglycemic; 31% died, 14% required mechanical ventilation.
  • Inpatient hyperglycemia was significantly associated with increased mortality and mechanical ventilation.
  • Adjusted analysis showed uncontrolled hyperglycemia increased mortality risk (HR 1.54) and MV risk (HR 4.41).

Conclusions:

  • Tight control of inpatient hyperglycemia may improve outcomes for diabetic patients hospitalized with COVID-19.
Abstract

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