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MER2: a red cell polymorphism defined by monoclonal antibodies.

G L Daniels, P Tippett, D K Palmer

    Vox Sanguinis
    |January 1, 1987
    PubMed
    Summary

    Researchers identified a new red blood cell polymorphism, MER2, found in 92% of English donors. This dominant genetic trait is located on chromosome 11.

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    Area of Science:

    • Immunology
    • Genetics
    • Hematology

    Background:

    • Monoclonal antibodies 1D12 and 2F7 recognize a novel red blood cell antigen.
    • This antigen defines a new red cell polymorphism, termed MER2.

    Purpose of the Study:

    • To characterize the MER2 red cell polymorphism.
    • Determine the inheritance pattern and genetic locus of MER2.

    Main Methods:

    • Serological analysis using murine monoclonal antibodies (1D12, 2F7).
    • Family studies to investigate inheritance patterns.
    • Somatic cell hybridization to map the gene locus.

    Main Results:

    • MER2 polymorphism identified in English blood donors (MER2+ frequency: 0.7159).

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  • MER2+ is inherited in a Mendelian dominant fashion.
  • MER2 antigen is present on some leukemia cell lines and fibroblasts.
  • Somatic cell hybrid analysis mapped the MER2 gene to chromosome 11p15.

    • Conclusions:

    • MER2 represents a newly discovered human red blood cell polymorphism.
    • The MER2 gene is located on chromosome 11p15 and exhibits dominant inheritance.
    • MER2 antigen expression extends beyond erythrocytes to certain cell lines.