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East Coast fever, a neglected tropical disease with an outdated vaccine approach?
Jeannine Kolakowski1, Tim Connelley2, Petra Lukacik3
1Centre for Vaccinology and Regenerative Medicine, Department of Pathobiology and Population Sciences, Royal Veterinary College, University of London, London, UK.
Abstract:
Since its discovery, bovine theileriosis has caused major socioeconomic losses in sub-Saharan Africa. Acaricide resistance of the intermediate host, paucity of therapeutics, and lack of sufficiently cross-protective vaccines increase the risk of parasite spread due to global warming. Here, we highlight three important areas that require investigation to develop next-generation vaccines.
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