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Updated: Aug 30, 2025

Mouse Models Of Helicobacter Infection And Gastric Pathologies
Published on: October 18, 2018
The complex immunological role of Helicobacter in modulating cancer
T W Hand1, A E Overacre-Delgoffe2
1University of Pittsburgh, Department of Immunology, Pittsburgh, PA, USA; Children's Hospital of Pittsburgh, RK Mellon Institute, Department of Pediatrics, Pittsburgh, PA, USA.
Abstract:
The gut microbiota has recently emerged as a unique mechanism of immunotherapeutic resistance or response within certain cancer patients. Certain adherent bacterial species that reside along the epithelial barrier within the gastrointestinal tract have been shown to be the most immunogenic and include several species within the Helicobacteraceae family. The role of these microbes in cancer remains controversial and varies according to species, immune status, and cancer type. Here, we hypothesize that the functional characteristics rather than the bacterial species of Helicobacteraceae dictate the type of immune response with either a benefit or a detriment to overall cancer progression.
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