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Autonomic dysfunction in progressive supranuclear palsy.

Francesca Baschieri1, Maria Vitiello2, Pietro Cortelli1,3

  • 1Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.

Journal of Neurology
|August 30, 2022
PubMed
Summary
This summary is machine-generated.

Progressive supranuclear palsy (PSP) patients often report autonomic dysfunction symptoms. However, objective tests indicate that these symptoms do not always reflect actual autonomic impairment in PSP.

Keywords:
Autonomic dysfunctionOrthostatic hypotensionPhotophobiaProgressive supranuclear palsyUrinary incontinence

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Area of Science:

  • Neuroscience
  • Autonomic Neurology

Background:

  • Autonomic nervous system involvement in Progressive Supranuclear Palsy (PSP) is poorly understood, with conflicting research findings.
  • Characterizing autonomic dysfunction in PSP is crucial for understanding this neurodegenerative disease and aiding differential diagnosis.

Purpose of the Study:

  • To systematically review and characterize autonomic nervous system dysfunction in Progressive Supranuclear Palsy (PSP).
  • To enhance the understanding of PSP's impact on patients and assist clinicians in differentiating it from other Parkinsonian syndromes.

Main Methods:

  • A systematic literature review was conducted using PubMed.
  • The review focused on studies investigating autonomic nervous system involvement in Progressive Supranuclear Palsy (PSP).

Main Results:

  • PSP patients frequently reported symptoms across all domains of autonomic dysfunction.
  • Cardiovascular autonomic testing revealed mild impairment in some cases; bladder dysfunction was noted, primarily in the storage phase.
  • Dysphagia, constipation, sudomotor, and pupillomotor disturbances were common, with instrumental tests supporting these findings.

Conclusions:

  • While PSP patients frequently report visceral symptoms, objective testing reveals these do not consistently correlate with actual autonomic impairment.
  • Further research is necessary to fully define the autonomic profile in PSP and its prognostic significance.