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Outcomes of Babies with Opioid Exposure (OBOE): protocol of a prospective longitudinal cohort study

Carla M Bann1, Jamie E Newman2, Brenda Poindexter3

  • 1RTI International, Research Triangle Park, NC, USA. cmb@rti.org.

Pediatric Research
|August 30, 2022
PubMed

Insights

Maternal opioid use impacts fetal brain development. The Outcomes of Babies with Opioid Exposure (OBOE) study tracks neurodevelopmental outcomes in infants exposed to opioids antenatally, identifying early biomarkers.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Pediatrics

Background:

  • The health and socioeconomic impacts of adult opioid addiction are recognized.
  • The effects of maternal opioid use on fetal development are less understood.
  • Prenatal opioid exposure poses risks to infant brain development.

Purpose of the Study:

  • To determine the impact of antenatal opioid exposure on infant brain development and neurodevelopmental outcomes up to 2 years of age.
  • To investigate how family, home, and community factors influence developmental trajectories in infants with prenatal opioid exposure.
  • To establish the Outcomes of Babies with Opioid Exposure (OBOE) Study protocol for a multi-site prospective longitudinal cohort study.

Main Methods:

  • Prospective longitudinal cohort study design comparing infants with antenatal opioid exposure to unexposed controls.
  • Serial MRI assessments from birth to 2 years to examine brain development trajectories.
  • Comprehensive neurodevelopmental assessments including cognitive, language, motor, and social-emotional skills.
  • Umbilical cord assays to accurately quantify prenatal opioid and substance exposure.

Main Results:

  • Primary outcomes include analysis of cortical volumes, deep gray matter volumes, and functional/structural brain connectivity using diffusion tensor imaging.
  • Neurodevelopmental outcomes assessed via the Bayley Scales of Infant Development and the Brief Infant-Toddler Social and Emotional Assessment.
  • Integration of MRI findings and neurodevelopmental assessments to identify early functional brain topography and potential biomarkers.

Conclusions:

  • The OBOE study protocol is designed to address limitations of previous research on prenatal opioid exposure.
  • This study will provide crucial insights into the effects of antenatal opioid exposure on early infant brain development.
  • Findings will enhance understanding of neurodevelopmental trajectories and identify potential biomarkers for early intervention.
Abstract

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