Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunological Memory01:23

Immunological Memory

3.6K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
3.6K
Active versus Passive Immunity01:31

Active versus Passive Immunity

3.3K
Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
3.3K
Cross-reactivity00:42

Cross-reactivity

31.4K
Overview
31.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bridging the Rural-Urban Divide: Independent Pharmacies and Women's Contraceptive Access.

Pharmacy (Basel, Switzerland)·2026
Same author

Research Speed Dating: Research Question Development for Primary Care Physicians.

Family medicine·2026
Same author

A breast cancer look-alike in primary care: Diagnosing idiopathic granulomatous mastitis.

Journal of family medicine and primary care·2026
Same author

Study Protocol for a Pain Self-Management Intervention to Reduce Pain and Improve MOUD Engagement in Primary Care: A Randomized Trial.

Substance use & addiction journal·2026
Same author

Lessons Learned From the Front Line of AI-Augmented Patient Messaging.

Annals of family medicine·2026
Same author

Enhancing Osteoporosis Screening in High-Risk Men Ages 50 Years and Older: A Clinical Decision Support and Workflow Integration Approach.

Journal of primary care & community health·2025

Related Experiment Video

Updated: Aug 30, 2025

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection
10:25

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection

Published on: June 5, 2021

4.8K

Seronegative immunity to SARS-CoV-2: a case study.

Kyle D Miller1, Amie M Ashcraft2, Courtney S Pilkerton1

  • 1Department of Family Medicine, Medical Center Drive, West Virginia University, Box 9152, Morgantown, WV, 26506, USA.

Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
|August 30, 2022
PubMed
Summary
This summary is machine-generated.

Investigating host factors in COVID-19 (coronavirus disease 2019) is crucial. Two geriatric patients with comorbidities showed no infection despite significant SARS-CoV-2 exposure, suggesting potential host resistance.

Keywords:
COVID-19CoronavirusImmunitySARS-CoV-2

More Related Videos

Author Spotlight: Studying Host-Virus Interactions with Pseudotyped Viruses
05:49

Author Spotlight: Studying Host-Virus Interactions with Pseudotyped Viruses

Published on: November 21, 2023

1.8K
Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
08:48

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Published on: February 16, 2022

3.0K

Related Experiment Videos

Last Updated: Aug 30, 2025

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection
10:25

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection

Published on: June 5, 2021

4.8K
Author Spotlight: Studying Host-Virus Interactions with Pseudotyped Viruses
05:49

Author Spotlight: Studying Host-Virus Interactions with Pseudotyped Viruses

Published on: November 21, 2023

1.8K
Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
08:48

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Published on: February 16, 2022

3.0K

Area of Science:

  • Geriatric Medicine
  • Infectious Diseases
  • Immunology

Background:

  • Coronavirus disease 2019 (COVID-19) exhibits a wide spectrum of clinical severity.
  • Mechanical ventilation for COVID-19 carries a high mortality rate (approximately 25%).
  • The influence of host factors on COVID-19 disease course remains incompletely understood.

Purpose of the Study:

  • To explore potential host factors influencing COVID-19 susceptibility and disease course.
  • To investigate resistance to SARS-CoV-2 infection in specific patient populations.

Main Methods:

  • Case report examining two geriatric patients residing in a long-term care facility.
  • Patients had multiple comorbid conditions and significant, unprotected exposure to SARS-CoV-2.
  • Diagnostic testing included PCR and antibody assays, both yielding negative results.

Main Results:

  • Both geriatric patients, despite extensive exposure to the virus, tested negative for SARS-CoV-2 via PCR and antibody tests.
  • This suggests a potential lack of susceptibility or rapid clearance of the virus in these individuals.

Conclusions:

  • These cases highlight the potential role of host resistance in modulating COVID-19 outcomes.
  • Further research is warranted to elucidate the specific host factors conferring resistance to SARS-CoV-2.
  • Understanding these factors could inform strategies for managing and preventing severe COVID-19.