Difference in macrophage migration inhibitory factor between preterm and term newborns and associating clinical
Ji Sook Park1,2, Jin Su Jun1,2, Jae Young Cho1,2
1Department of Pediatrics, Gyeongsang National University College of Medicine and Gyeongsang National University Hospital, Jinju, South Korea.
Abstract:
This study aimed to investigate the macrophage migration inhibitory factor (MIF) and associated clinical factors in neonates. Clinical information and blood samples were obtained from 77 neonates. Clinical details were reviewed from medical records, and MIF was measured by enzyme-linked immunosorbent assay using blood samples acquired within a week after birth. Statistical analyses were performed between plasma MIF concentration and clinical factors. Among the 77 newborn infants, 25 were born at <34 weeks of gestation (preterm), 25 at 34 to 37 weeks (late preterm), and 27 at term gestation. The mean MIF was 9849.5 ± 7187.8 pg/mL in preterm, 5718.7 ± 4596.4 in late preterm, and 5361.1 ± 3895.7 in term infants (P = .016). Among 25 preterm infants born at <34 weeks of gestation, MIF was significantly higher in infants with necrotizing enterocolitis (NEC, 19,478.6 ± 8162.4 pg/mL, n = 5) than that in infants without NEC (feeding intolerance 7173.7 ± 4203.0 pg/mL, n = 12 and others 7844.9 ± 5311.2 pg/mL, n = 8, P = .020). Elevated plasma MIF levels in the transitional period were significantly associated with preterm birth before 34 weeks of gestation and the development of NEC.
Insights
Elevated macrophage migration inhibitory factor (MIF) in newborns is linked to premature birth and necrotizing enterocolitis (NEC). Higher MIF levels were observed in preterm infants, particularly those who developed NEC.
Area of Science:
- Neonatal research
- Immunology
- Clinical biochemistry
Background:
- Macrophage migration inhibitory factor (MIF) plays a role in inflammatory responses.
- Understanding neonatal inflammatory markers is crucial for identifying at-risk infants.
Purpose of the Study:
- To investigate plasma MIF levels in neonates.
- To explore associations between MIF and clinical factors, including gestational age and necrotizing enterocolitis (NEC).
Main Methods:
- Blood samples were collected from 77 neonates within one week of birth.
- Plasma MIF concentrations were measured using enzyme-linked immunosorbent assay (ELISA).
- Statistical analyses correlated MIF levels with clinical data.
Main Results:
- Mean MIF levels were significantly higher in preterm infants (<34 weeks gestation) compared to late preterm and term infants (P = .016).
- Among preterm infants, those who developed NEC showed significantly higher MIF levels than those without NEC (P = .020).
Conclusions:
- Elevated plasma MIF in the transitional period is associated with preterm birth (<34 weeks gestation).
- Increased MIF levels are significantly linked to the development of NEC in preterm neonates.
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