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Assessing the Global Impact on the Mouse Kidney After Traumatic Brain Injury: A Transcriptomic Study
Wei-Hung Chan1,2, Yu-Juei Hsu3, Chiao-Pei Cheng1
1Department of Anesthesiology, Tri-Service General Hospital, National Defense Medical Center, Taipei City, Taiwan, Republic of China.
Journal of Inflammation Research
|August 31, 2022
Summary
Traumatic brain injury (TBI) impacts kidney gene expression, affecting mitochondrial function and immune cell activity. This research reveals TBI
Area of Science:
- Nephrology
- Neuroscience
- Bioinformatics
Background:
- Traumatic brain injury (TBI) can lead to systemic complications.
- The kidney's response to TBI is not well understood.
Purpose of the Study:
- To investigate renal transcriptional changes following TBI using animal models.
- To identify specific gene sets and pathways affected by TBI in the kidney.
Main Methods:
- Utilized a mouse model of unilateral controlled cortical impact for TBI induction.
- Performed microarray analysis and multi-oriented gene set enrichment analysis on kidney tissue.
- Simulated immune cell infiltration analysis was conducted.
Main Results:
- TBI altered mitochondrial function gene sets in kidney cells, linked to lactate metabolism.
- Observed negative enrichment in immune cell migration and epidermal development gene sets.
- Increased infiltration of activated memory CD4 T cells and complement system activation were noted, suggesting autoinflammation.
Conclusions:
- This study is the first to demonstrate TBI's effect on renal gene expression.
- TBI may induce kidney damage via mitochondrial dysfunction and immune cell infiltration.
- Mechanisms involving lactate metabolism and complement system activation are implicated in TBI-induced kidney injury.
