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Specific impact of cardiovascular risk factors on coronary microcirculation in patients with subclinical

Mirjana Stojković1, Biljana Nedeljković-Beleslin1, Milorad Tešić1

  • 1University of Belgrade, Faculty of Medicine, Belgrade.

Journal of Medical Biochemistry
|August 31, 2022
PubMed

Insights

Subclinical hypothyroidism (SCH) does not alter coronary flow reserve (CFR) but changes how cardiovascular risk factors impact CFR, suggesting altered microvascular sensitivity in SCH patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Vascular Biology

Background:

  • Thyroid hormones significantly influence the cardiovascular system.
  • The specific impact of subclinical hypothyroidism (SCH) on cardiovascular function, particularly coronary flow reserve (CFR), requires further investigation.

Purpose of the Study:

  • To investigate coronary flow reserve (CFR) in patients with subclinical hypothyroidism (SCH).
  • To determine if cardiovascular risk factors have a differential impact on CFR in SCH patients compared to healthy controls.

Main Methods:

  • Thirty-two patients with SCH and 18 healthy controls were studied.
  • Coronary flow reserve (CFR) was measured using Doppler echocardiography after adenosine infusion.
  • Serum levels of thyroid hormones, glucose metabolism markers, lipids, and C-reactive protein were assessed.

Main Results:

  • Coronary flow reserve (CFR) did not significantly differ between SCH patients and controls.
  • In SCH patients, CFR correlated significantly with waist-to-hip ratio, hypertension, smoking, glucose status markers, and lipid profiles.
  • In controls, only cholesterol levels showed a significant correlation with CFR; no correlation was found between CFR and thyroid hormones in either group.

Conclusions:

  • Subclinical hypothyroidism (SCH) alters the impact of cardiovascular risk factors on coronary flow reserve (CFR).
  • Patients with SCH and healthy individuals exhibit different responses to cardiovascular risk factors.
  • Altered thyroid axis set points in SCH may change microvascular sensitivity to known risk factors.
Abstract

Keywords:
cardiovascular risk factorscoronary flow reservesubclinical hypothyroidismthyroid

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