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Genetic polymorphism of matrix metalloproteinase 9 and susceptibility to chronic obstructive pulmonary disease: A

Xiaoping Yang1, Yuanyuan Yu2, Yong Wang1

  • 1Qingdao Hospital of Traditional Chinese Medicine (Haici Hospital), Department 2 of Respiratory and Critical Care (Lung disease) Center, Qingdao, China.

Journal of Medical Biochemistry
|August 31, 2022
PubMed
Abstract

Insights

Genetic variations in matrix metalloproteinase 9 (MMP9) were analyzed for chronic obstructive pulmonary disease (COPD) risk. The TT genotype of MMP9 rs3918242 was associated with lower COPD susceptibility in Chinese populations.

Area of Science:

  • Genetics
  • Pulmonology
  • Molecular Biology

Background:

  • Chronic obstructive pulmonary disease (COPD) is a major global health concern.
  • Matrix metalloproteinase 9 (MMP9) is implicated in lung tissue remodeling and inflammation, key processes in COPD pathogenesis.
  • Genetic polymorphisms in MMP9 may influence individual susceptibility to COPD.

Purpose of the Study:

  • To systematically evaluate the association between genetic polymorphisms of matrix metalloproteinase 9 (MMP9) and the risk of developing chronic obstructive pulmonary disease (COPD).

Main Methods:

  • A comprehensive literature search was conducted across major scientific databases (PubMed, Web of Science, VIP, Wanfang, CNKI) using relevant keywords.
  • Eligible studies investigating MMP9 gene variations and COPD susceptibility were identified and data extracted.
  • Meta-analysis was performed to calculate the odds ratio (OR) and 95% confidence interval (CI) for the association.

Main Results:

  • Sixteen independent studies involving MMP9-1562C/T polymorphism and COPD were analyzed.
  • Overall, no significant association was found between MMP9-1562C/T and COPD susceptibility across all genetic models.
  • However, subgroup analysis revealed a significantly lower risk of COPD in the Chinese population with the TT genotype of MMP9 rs3918242 compared to CT and CC genotypes (OR=0.67, 95% CI=0.46-0.97).

Conclusions:

  • The TT genotype of the MMP-9 rs3918242 polymorphism is associated with reduced susceptibility to COPD in the Chinese population.
  • Further research may be warranted to elucidate the specific mechanisms underlying this protective effect.
Keywords:
COPDMMP9meta-analysispolymorphism

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