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Fabricating Optical-quality Glass Surfaces to Study Macrophage Fusion
Published on: March 14, 2018
Effect of water-soluble fullerenes on macrophage surface ultrastructure revealed by scanning ion conductance
Hefei Ruan1,2, Xuejie Zhang3, Jinghe Yuan1
1Key Laboratory of Molecular Nanostructure and Nanotechnology, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences Beijing China ruanhefei@iccas.ac.cn xfang@iccas.ac.cn.
Abstract:
C60-fullerenes have unique potential in antiviral, drug delivery, photodynamic therapy and other biomedical applications. However, little is known about their effects on macrophage surface morphology and ultrastructure. Here by using contact-free scanning ion conductance microscopy (SICM), we investigated the effects of two water-soluble fullerenes on the surface ultrastructure and function of macrophages. The results showed that these fullerenes would be a promising phagocytosis inhibitor and SICM would be an excellent tool to study the morphological information of adhesive and fragile samples.
