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A Human Fallopian Tube Model for Investigation of C. trachomatis Infections
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Association between Chlamydia trachomatis Infection and Male Infertility: A Systematic Review and Meta-Analysis

Masoud Keikha1, Seyed-Abolfazl Hosseininasab-Nodoushan2, Amirhossein Sahebkar3,4,5,6

  • 1Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Mini Reviews in Medicinal Chemistry
|August 31, 2022
PubMed
Abstract

Insights

Chlamydia trachomatis infection is prevalent in infertile men, significantly increasing their risk of infertility. This study confirms a strong association between C. trachomatis and male infertility, highlighting its public health importance.

Area of Science:

  • Reproductive Medicine
  • Infectious Diseases
  • Urology

Background:

  • Chlamydia trachomatis is a common sexually transmitted infection with emerging evidence linking it to sperm dysfunction.
  • The role of C. trachomatis infection in male infertility remains debated despite existing research.
  • Understanding the prevalence and impact of C. trachomatis is crucial for reproductive health strategies.

Approach:

  • A comprehensive systematic literature search was conducted across major scientific databases.
  • Eligibility criteria were applied to select relevant studies for meta-analysis.
  • Statistical analysis was performed to determine the prevalence and odds ratio of infertility associated with C. trachomatis.

Key Points:

  • The pooled prevalence of C. trachomatis infection in infertile males was found to be 20.6%.
  • C. trachomatis infection was associated with a significantly increased risk of male infertility (OR: 2.28).
  • The findings indicate a robust link between C. trachomatis and male infertility.

Conclusions:

  • C. trachomatis infection is highly prevalent in sperm and semen samples of infertile men.
  • The study concludes that C. trachomatis infection significantly elevates the risk of infertility in men.
  • These findings underscore the importance of screening and managing C. trachomatis in cases of male infertility.
Keywords:
Chlamydia trachomatisinfectioninfertilitymeta-analysisprevalencesperm

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