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Updated: Aug 30, 2025
Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
Published on: October 2, 2018
Total Synthesis of Resiniferatoxin
Vasil H Vasilev1, Lukas Spessert1, Kuan Yu1
1Department of Chemistry, University of California-Berkeley, 826 Latimer Hall, Berkeley, California 94720, United States.
Abstract:
From both structural and functional perspectives, the large family of daphnane diterpene orthoesters (DDOs) represent a truly remarkable class of natural products. As potent lead compounds for the treatment of pain, neurodegeneration, HIV/AIDS, and cancer, their medicinal potential continues to be heavily investigated, yet synthetic routes to DDO natural products remain rare. Herein we report a distinct approach to this class of complex diterpenes, highlighted by a 15-step total synthesis of the flagship DDO, resiniferatoxin.
