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Responsive hydrogel-based three-dimensional photonic crystal sensor for lactic acid detection.

Qi Li1, Songtao Liu1, Nyv Mondele Mbola1

  • 1School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 102488, China.

Analytical and Bioanalytical Chemistry
|August 31, 2022
PubMed
Summary

A new hydrogel sensor detects lactic acid with a visible color change in minutes. This cost-effective sensor offers high selectivity and reusability for disease diagnosis and food safety applications.

Keywords:
HydrogelLactic acid detectionOxamate derivativePhotonic crystalTheoretical calculation

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Area of Science:

  • Materials Science
  • Analytical Chemistry
  • Biomedical Engineering

Background:

  • Lactic acid detection is crucial for disease diagnosis and food quality control.
  • Existing methods may lack specificity, speed, or cost-effectiveness.
  • Development of novel sensors is essential for improved monitoring.

Purpose of the Study:

  • To develop a hydrogel-based three-dimensional photonic crystal (PC) sensor for specific lactic acid detection.
  • To evaluate the sensor's performance in terms of response time, detection limit, and reusability.
  • To confirm the sensor's selectivity and affinity for lactic acid.

Main Methods:

  • Fabrication of a hydrogel using N-isopropylacrylamide, acrylamide, and an oxamate derivative (AOA).
  • Utilizing a three-dimensional photonic crystal structure for optical sensing.
  • Employing density functional theory (DFT) to study molecular interactions.
  • Testing sensor response to varying lactic acid concentrations and interfering substances.

Main Results:

  • The sensor exhibited a distinct color change from orange-red to purple upon exposure to lactic acid.
  • A 45-nm redshift in the reflection peak was observed within 3 minutes for concentrations up to 20 mM.
  • A low detection limit of 0.1 mM was achieved.
  • The sensor demonstrated high selectivity for lactic acid over pyruvate and propionic acid.
  • The sensor was reusable for over 20 cycles.

Conclusions:

  • The developed hydrogel-based PC sensor provides a rapid, cost-effective, and selective method for lactic acid determination.
  • The sensor's optical response and DFT analysis confirm its specificity.
  • This technology holds promise for practical applications in diagnostics and food safety.