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Related Concept Videos

Mismatch Repair01:20

Mismatch Repair

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Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
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Non-LTR Retrotransposons03:18

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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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Related Experiment Video

Updated: Aug 30, 2025

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

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Association Between Low-Dose Methotrexate Exposure and Melanoma: A Systematic Review and Meta-analysis.

Mabel K Yan1,2, Charlie Wang1,2, Rory Wolfe2

  • 1Victorian Melanoma Service, The Alfred Hospital, Melbourne, Victoria, Australia.

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Low-dose methotrexate, used for inflammatory conditions, is linked to a slight increase in melanoma risk. However, the overall absolute risk remains very small.

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Area of Science:

  • Dermatology
  • Rheumatology
  • Oncology

Background:

  • Methotrexate is a common treatment for inflammatory disorders like rheumatoid arthritis.
  • Previous studies suggest a potential link between methotrexate use and an elevated melanoma risk.

Conclusions:

  • Low-dose methotrexate use is associated with a statistically significant but small increase in melanoma risk.
  • The absolute increase in melanoma risk attributable to methotrexate is considered negligible.
  • Further research may be warranted to fully elucidate the risk-benefit profile in specific patient populations.