Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

122
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
122
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

147
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
147
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

908
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
908
Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

2.1K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.1K
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

149
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
149
Liver Physiology01:30

Liver Physiology

925
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
925

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Drug research·2021
Same author

Bile Acids Activate NLRP3 Inflammasome, Promoting Murine Liver Inflammation or Fibrosis in a Cell Type-Specific Manner.

Cells·2021
Same author

[The use of immuno-oncologic therapy in hepatocellular carcinoma in the context of liver transplantation. An interdisciplinary benefit/risk assessment].

Zeitschrift fur Gastroenterologie·2021
Same author

Haemorrhagic ulcerative duodenitis in a patient with COVID-19 infection: clinical improvement following treatment with budesonide.

BMJ open gastroenterology·2021
Same author

Molecular and Cellular Mediators of the Gut-Liver Axis in the Progression of Liver Diseases.

Frontiers in medicine·2021
Same author

[Management of acutely decompensated liver cirrhosis in emergency and critical care medicine].

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2021

Related Experiment Video

Updated: Aug 30, 2025

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit
06:52

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Published on: September 30, 2020

9.9K

[Liver dysfunction in geriatric patients].

Philipp Kasper1, Frank Tacke2, Hans Jürgen Heppner3,4

  • 1Klinik für Gastroenterologie und Hepatologie, Medizinische Fakultät und Uniklinik Köln, Universität zu Köln, Köln, Deutschland. philipp.kasper@uk-koeln.de.

Zeitschrift Fur Gerontologie Und Geriatrie
|August 31, 2022
PubMed
Summary

As people age, liver function declines, increasing vulnerability to toxins and impairing regeneration. Prompt diagnosis of liver dysfunction in older adults is crucial for effective treatment and preventing complications.

Keywords:
AgingFrailtyHepatologyLiverNon-alcoholic fatty liver diseaseSarcopenia

More Related Videos

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
11:06

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

4.6K
An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
08:59

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

8.0K

Related Experiment Videos

Last Updated: Aug 30, 2025

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit
06:52

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Published on: September 30, 2020

9.9K
Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
11:06

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

4.6K
An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
08:59

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

8.0K

Area of Science:

  • Gerontology
  • Hepatology
  • Internal Medicine

Background:

  • Aging is associated with widespread physiological changes, including alterations in cardiovascular, neurocognitive, and musculoskeletal systems.
  • Hepatic organ function also undergoes age-related morphological and functional changes.
  • These changes can lead to progressive hepatic dysfunction, increased susceptibility to harmful substances, and reduced regenerative capacity.

Purpose of the Study:

  • To highlight the age-related changes in hepatic organ function.
  • To identify common causes of liver dysfunction in the geriatric population.
  • To emphasize the importance of timely diagnosis and treatment for liver dysfunction in older adults.

Main Methods:

  • Review of age-related changes in hepatic physiology.
  • Analysis of common etiologies of liver disease in the elderly.
  • Discussion of diagnostic and therapeutic implications.

Main Results:

  • Aging impacts liver structure and function, leading to decreased resilience.
  • Non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease, viral hepatitis, autoimmune hepatitis, and drug-induced liver injury are frequent causes of liver dysfunction in geriatric patients.
  • Impaired regenerative capacity and increased vulnerability to toxins are characteristic of aging livers.

Conclusions:

  • Prompt diagnostic evaluation is essential for identifying the cause of liver dysfunction in older individuals.
  • Timely intervention can mitigate progressive hepatic impairment and associated complications.
  • Understanding age-related hepatic changes is critical for managing liver health in the geriatric population.