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Updated: Aug 30, 2025

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Research on electroacupuncture parameters for knee osteoarthritis based on data mining.

Fei-Hong Cai1, Fan-Lian Li1, Yu-Chen Zhang1

  • 1College of Acupuncture and Tuina, Shanghai University of TCM, Shanghai, 201203, China.

European Journal of Medical Research
|August 31, 2022
PubMed
Summary

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Electroacupuncture shows promise for knee osteoarthritis, with common parameters including a 2 Hz low frequency and 30-minute sessions. Optimal acupoint selection and further research are key for effective treatment.

Area of Science:

  • Integrative and Complementary Medicine
  • Rehabilitation Medicine
  • Pain Management

Background:

  • Knee osteoarthritis (KO) is a prevalent degenerative joint disease.
  • Electroacupuncture (EA) is increasingly used for KO treatment.
  • Current EA parameter variability hinders standardized clinical application.

Purpose of the Study:

  • To identify optimal electroacupuncture stimulation parameters for knee osteoarthritis.
  • To apply data mining techniques to synthesize clinical study data.
  • To establish evidence-based guidelines for EA in KO management.

Main Methods:

  • Systematic literature search of four databases (PubMed, Cochrane, Embase, Web of Science) from 2012-2021.
  • Data compilation using Microsoft Excel 2020.
Keywords:
Data miningElectroacupunctureKnee osteoarthritisParameter

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  • Statistical analysis performed using R Version 4.1.1.

    • Main Results:

    • Forty-six clinical studies were included.
    • Frequently used parameters: 0.30 mm × 40 mm needle, continuous wave, 2 Hz low frequency, 30-minute duration, daily treatment.
    • Key acupoints: Dubi (ST35), Liangqiu (ST34), Neixiyan (EX-LE4), Xuehai (SP10), Yanglingquan (GB34), Yinlingquan (SP9).
    • Cluster analysis identified obligatory and adjunctive acupoint groups.
    • Liangqiu (ST34) and Xuehai (SP10) identified as a highly associated acupoint pair.

    Conclusions:

    • Optimal EA parameters for KO include continuous wave, 2 Hz low frequency, 30-minute sessions, and local acupoint selection.
    • Further large-scale, multi-centered, and standardized clinical trials are recommended.
    • Standardization of EA parameters is crucial for consistent clinical outcomes in KO treatment.