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Diclofenac induced anaphylaxis: A case report from Nepal.
Himal Bikram Bhattarai1, Sangam Shah2, Manish Uprety3
1Gandaki Medical College and Teaching Hospital, Pokhara, Nepal.
Annals of Medicine and Surgery (2012)
|September 1, 2022
Summary
Diclofenac is generally safe, but a rare case shows it can cause severe anaphylactic reactions, even after intravenous administration. Prompt diagnosis and evaluation are crucial for managing such adverse drug events.
Area of Science:
- Pharmacology
- Clinical Medicine
- Immunology
Background:
- Diclofenac is a widely used nonsteroidal anti-inflammatory drug (NSAID).
- While generally safe, NSAIDs carry potential risks, including hypersensitivity reactions.
- Anaphylaxis is a severe, potentially life-threatening allergic reaction.
Observation:
- A case report details a 40-year-old male experiencing an anaphylactic reaction.
- The reaction occurred following intravenous administration of diclofenac sodium.
- This highlights a rare but serious adverse effect of the medication.
Findings:
- Anaphylaxis involves rapid, systemic mast cell activation.
- Mast cell activation releases mediators like histamine and tryptase.
- Elevated tryptase levels can serve as a marker for anaphylaxis.
Implications:
- Intravenous diclofenac, despite its common use, can precipitate severe anaphylactic responses.
- Healthcare providers must be vigilant for anaphylaxis in patients receiving diclofenac.
- Thorough diagnostic evaluation is essential when suspecting anaphylaxis or similar severe reactions.
