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Drug Utilization Evaluation (DUE) of vancomycin: A cross-sectional study
Mina Rezvani1,2, Ali Kharazmkia2, Ali Amiri3
1School of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran.
Annals of Medicine and Surgery (2012)
|September 1, 2022
Summary
This drug utilization evaluation of vancomycin found significant deviations from treatment guidelines in both children and adults. Adhering to international standards is recommended to improve antibiotic use and prevent resistance.
Area of Science:
- Pharmacology
- Infectious Diseases
- Clinical Pharmacy
Background:
- Evaluating antibiotic use is crucial for identifying drug-related issues, combating antibiotic resistance, and managing medication costs.
- Vancomycin is a critical antibiotic, necessitating careful evaluation of its utilization.
Purpose of the Study:
- To conduct a Drug Utilization Evaluation (DUE) of vancomycin in a patient population.
- To assess the adherence to established guidelines for vancomycin dosing, duration, and indications.
Main Methods:
- A descriptive, retrospective, cross-sectional study design was employed.
- A census sampling method was used, collecting data via checklists and patient file reviews.
Main Results:
- Vancomycin dosing, duration, and indication adherence to Uptodate guidelines varied significantly in both pediatric (10.6%-18.8%) and adult (30%-61%) populations.
- Common initial diagnoses included RDS and pneumonia in children, and CRF and catheter-related issues in adults.
- Observed complications included shortness of breath, fever, jaundice in children, and fever, lethargy, and shortness of breath in adults.
Conclusions:
- There is a need to enhance the administration and rational use of vancomycin.
- Implementing treatment protocols aligned with international standards is recommended to mitigate microbial resistance.
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