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Plasma fibronectin concentration in normal pregnancy and pre-eclampsia
Acta Obstetricia Et Gynecologica Scandinavica
|January 1, 1987
Summary
Plasma fibronectin levels increase during normal pregnancy. Significantly elevated fibronectin concentrations in pre-eclampsia patients suggest its potential as a diagnostic marker for this condition.
Area of Science:
- Biochemistry
- Obstetrics
- Clinical Diagnostics
Background:
- Plasma fibronectin is a glycoprotein involved in cell adhesion and wound healing.
- Changes in fibronectin levels during pregnancy are not fully understood.
- Pre-eclampsia is a serious pregnancy complication characterized by hypertension and proteinuria.
Purpose of the Study:
- To investigate plasma fibronectin concentrations in normal pregnancy and pre-eclampsia.
- To assess the potential diagnostic value of plasma fibronectin in pre-eclampsia.
Main Methods:
- Electroimmunoassay was used to measure plasma fibronectin concentration.
- Study included 111 normal pregnant women and 23 pregnant women with pre-eclampsia.
Main Results:
- Plasma fibronectin concentration significantly increased during normal pregnancy.
- Patients with mild or severe pre-eclampsia exhibited significantly higher plasma fibronectin levels compared to normal pregnancy at 38-41 weeks gestation.
Conclusions:
- Plasma fibronectin levels are elevated in pre-eclampsia.
- Measurement of plasma fibronectin may serve as a valuable diagnostic tool for pre-eclampsia.