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Related Concept Videos

Allergic Drug Reactions01:27

Allergic Drug Reactions

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Allergic Reactions02:06

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Overview
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Hypersensitivities01:30

Hypersensitivities

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Related Experiment Video

Updated: Aug 30, 2025

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response
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Emicizumab-induced photosensitivity.

Pedro Asensi Cantó1, Mercedes Rodríguez Serna2, Pilar Lloret Madrid1

  • 1Unidad de Hemostasia y Trombosis, Servicio de Hematología, Hospital La Fe, Valencia, Spain.

TH Open : Companion Journal to Thrombosis and Haemostasis
|September 1, 2022
PubMed
Summary

Emicizumab is an effective prophylaxis for hemophilia A. This case report details a rare photosensitivity side effect caused by emicizumab, requiring permanent sun avoidance.

Keywords:
hemophilia A/Bhemophilia therapyhemostasis

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Area of Science:

  • Hematology
  • Pharmacology
  • Dermatology

Background:

  • Hemophilia A is a genetic bleeding disorder.
  • Emicizumab offers a novel prophylactic treatment option for hemophilia A patients, including those with inhibitors.
  • Understanding treatment side effects is crucial for patient management.

Purpose of the Study:

  • To report a case of photosensitivity induced by emicizumab.
  • To highlight a previously undocumented adverse event associated with emicizumab prophylaxis.
  • To emphasize the importance of monitoring for and reporting rare side effects.

Main Methods:

  • Case report detailing a patient's experience with emicizumab.
  • Clinical observation of adverse drug reactions.
  • Literature review for previously reported side effects.

Main Results:

  • The patient developed photosensitivity attributed to emicizumab treatment.
  • The photosensitivity necessitated permanent avoidance of sun exposure.
  • This adverse event appears to be a novel finding in the context of emicizumab therapy.

Conclusions:

  • Emicizumab, while effective, can cause rare side effects like photosensitivity.
  • Healthcare providers should be vigilant for and report such unforeseen adverse events.
  • Permanent sun-exposure suppression may be required in affected individuals.