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Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
Published on: July 28, 2023
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Emerging roles of long non-coding RNAs in keloids
Xin Yu1, Xueqing Zhu1, Hongjun Xu1
1Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Frontiers in Cell and Developmental Biology
|September 1, 2022
Summary
Keloids result from abnormal wound healing, characterized by fibroblast overgrowth and excess collagen. Research highlights that dysregulated long non-coding RNAs (lncRNAs) are implicated in keloid formation, offering potential therapeutic targets.
Area of Science:
- Dermatology
- Molecular Biology
- Genetics
Background:
- Keloids are pathological wound healing conditions.
- Fibroblast hyperproliferation and excessive collagen deposition characterize keloids.
- These conditions cause significant psychosocial and functional distress.
Purpose of the Study:
- To review the role of deregulated long non-coding RNAs (lncRNAs) in keloid formation.
- To explore lncRNA-based therapeutic strategies for keloids.
Main Methods:
- Literature review of studies on lncRNAs and keloids.
- Analysis of the pathomechanisms involving extracellular matrix (ECM) deposition and fibroblast proliferation.
Main Results:
- Accumulating evidence implicates deregulated lncRNAs in keloid pathogenesis.
- LncRNAs are involved in key processes like fibroblast proliferation and ECM deposition.
Conclusions:
- Deregulated lncRNAs are significant contributors to keloid development.
- Targeting lncRNAs presents a promising avenue for novel keloid therapies.
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