Related Experiment Video

Updated: Aug 30, 2025

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

524

Research Progress of PI3K/PTEN/AKT Signaling Pathway Associated with Renal Cell Carcinoma

Yakun Fang1, Wenjun Ji1, Chao Yan2

  • 1Department of Obstetrics, Qingdao Municipal Hospital, Qingdao 266000, China.

Disease Markers
|September 1, 2022
PubMed

Insights

Targeted therapies targeting the Phosphatidylinositol 3-kinase/Phosphatase and tensin homolog/Protein kinase B (PI3K/PTEN/AKT) pathway show promise for treating renal cell carcinoma, a common kidney cancer. This review explores its application to improve treatment efficacy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Renal cell carcinoma (RCC) is a prevalent and aggressive kidney cancer.
  • The Phosphatidylinositol 3-kinase/Protein kinase B (PI3K/AKT) signaling pathway is implicated in various cancers.
  • Phosphatase and tensin homolog (PTEN) negatively regulates the PI3K/AKT pathway, impacting cell proliferation and apoptosis.

Purpose of the Study:

  • To review the role of the PI3K/PTEN/AKT signaling pathway in renal cell carcinoma (RCC) development.
  • To explore targeted therapeutic strategies for RCC based on this pathway.
  • To provide references for clinical treatment of RCC.

Main Methods:

  • Literature review of studies on the PI3K/PTEN/AKT pathway in renal cell carcinoma.
  • Analysis of the pathway's involvement in RCC pathogenesis and progression.
  • Evaluation of potential targeted therapies for RCC.

Main Results:

  • The PI3K/PTEN/AKT pathway is frequently dysregulated in renal cell carcinoma.
  • PTEN acts as a tumor suppressor by inhibiting the PI3K/AKT pathway.
  • Targeting this pathway offers potential for novel RCC treatments.

Conclusions:

  • The PI3K/PTEN/AKT pathway is a critical regulator in renal cell carcinoma.
  • Understanding this pathway is essential for developing effective targeted therapies.
  • Further research into PI3K/PTEN/AKT targeted treatments may improve RCC patient outcomes.

More Related Videos

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers12:22

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers

Published on: January 22, 2013

33.7K
Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane05:36

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Published on: February 8, 2020

9.1K

Related Concept Videos

PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
3.9K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.9K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.4K
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
9.2K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
8.9K