Related Experiment Video

Updated: Aug 30, 2025

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
11:32

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Published on: March 27, 2020

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Targeting transcription factors in cancer drug discovery

Partha Mitra1

  • 1Institute of Health and Biomedical Innovation, the Queensland University of Technology, Brisbane 4059, Australia.

Exploration of Targeted Anti-Tumor Therapy
|September 1, 2022
PubMed

Insights

Researchers are developing new cancer drugs targeting transcription factors, previously considered undruggable. Recent advancements show promising pre-clinical results, advancing these novel cancer therapeutics toward clinical trials.

Area of Science:

  • Oncology
  • Molecular Biology
  • Drug Discovery

Background:

  • Cancer drug discovery relies heavily on clinical trials and research.
  • Transcription factors are historically challenging targets in drug development due to their 'undruggable' nature.
  • Recent technological advancements are beginning to overcome these challenges.

Purpose of the Study:

  • To review recent studies focused on targeting transcription factors in cancer.
  • To highlight the promising outcomes of these novel therapeutic strategies.

Main Methods:

  • Literature review of recently reported studies.
  • Analysis of pre-clinical data for drug candidates targeting transcription factors.

Main Results:

  • Several potential drug candidates targeting transcription factors have emerged.
  • These candidates show promising pre-clinical results.

Conclusions:

  • Targeting transcription factors is a viable and emerging strategy in cancer drug discovery.
  • Advanced technologies are key to unlocking the therapeutic potential of these targets.
Keywords:
Transcription factordrug discoverygene expressionprotein-protein interaction

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