Related Experiment Video
Updated: Aug 30, 2025
Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization
Published on: August 11, 2023
Acute macular neuroretinopathy associated with intravitreal anti-VEGF injection: A case report
Loubna M Radwan1, Ghazi O Bou Ghanem1, Ghassan N Daye1
1LAU Gilbert and Rose-Marie Chagoury School of Medicine, LAUMC/RH, Beirut, Lebanon, LAU Medical Center-Rizk Hospital, P.O. Box 11-3288, Beirut, Lebanon.
Purpose:
to report a case of acute macular neuroretinopathy occurring after intravitreal aflibercept injection for macular edema due to CRVO.
Observations:
Two days after Aflibercept intravitreal injection, the patient developed vision loss associated with a central scotoma. Optical coherence tomography showed a hyperreflective band at the level of the outer nuclear/outer plexiform layer corresponding to the patient's scotoma, ruling in the diagnosis of acute macular neuroretinopahty. Even though the OCT abnormalities resolved spontaneously, only partial resolution of the scotoma was observed 4 months later.
Conclusions And Importance:
Acute macular neuroretinopathy might be associated with intravitreal anti-VEGF injection.
