Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cerebrospinal Fluid01:21

Cerebrospinal Fluid

2.8K
Cerebrospinal fluid (CSF) is a colorless liquid that flows around the brain and the spinal cord, playing a vital role in the protection, support, and overall function of the central nervous system (CNS). CSF production, circulation, and absorption are tightly regulated processes essential for the brain and spinal cord to function properly.
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain....
2.8K
Anatomy of the Brain: Ventricles01:18

Anatomy of the Brain: Ventricles

5.0K
There are hollow fluid-filled cavities known as ventricles deep inside the human brain. There are two lateral ventricles, one in each cerebral hemisphere, and each has three different projections — the anterior, inferior, and posterior horns visible from the lateral side. A thin membrane called the septum pellucidum separates the two lateral ventricles. The slender third ventricle in the diencephalon is connected to each lateral ventricle via a channel called the interventricular foramen.
5.0K
Anatomy of the Eyeball01:20

Anatomy of the Eyeball

7.4K
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
7.4K
Glaucoma: Overview01:25

Glaucoma: Overview

704
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
704
Cranial and Spinal Meninges01:19

Cranial and Spinal Meninges

1.7K
The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
1.7K
The Blood-brain Barrier00:49

The Blood-brain Barrier

48.1K
Overview
48.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Momentum-dependent multiple gaps in magnesium diboride probed by electron tunnelling spectroscopy.

Nature communications·2012
Same author

Effect of antisense oligodeoxynucleotide targeted against NF-κB/P65 on cell proliferation and tumorigenesis of gastric cancer.

Clinical and experimental medicine·2012
Same author

Innate immunity alone is not sufficient for chronic rejection but predisposes healed allografts to T cell-mediated pathology.

Transplant immunology·2012
Same author

Electroacupuncture improves survival in rats with lethal endotoxemia via the autonomic nervous system.

Anesthesiology·2012
Same author

Single-incision laparoscopic Roux-en-Y hepaticojejunostomy using conventional instruments for children with choledochal cysts.

Surgical endoscopy·2011
Same author

Coherent spin precession via photoinduced antiferromagnetic interactions in La0.67Ca0.33MnO3.

Physical review letters·2011

Related Experiment Video

Updated: Aug 30, 2025

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
08:55

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments

Published on: April 24, 2020

3.1K

Cerebrospinal fluid dynamics along the optic nerve.

Jinqiao Sheng1,2, Qi Li1, Tingting Liu1

  • 1Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.

Frontiers in Neurology
|September 1, 2022
PubMed
Summary

Cerebrospinal fluid (CSF) circulation is vital for brain health, and its disruption can lead to neurological disorders like Alzheimer's and glaucoma. This review details CSF pathways, imaging, and computational models, focusing on the optic nerve.

Keywords:
cerebrospinal fluideye movementglymphatic systemoptic nervesubarachnoid space

More Related Videos

Three-Dimensional Imaging of the Vertebral Lymphatic Vasculature and Drainage using iDISCO+ and Light Sheet Fluorescence Microscopy
10:05

Three-Dimensional Imaging of the Vertebral Lymphatic Vasculature and Drainage using iDISCO+ and Light Sheet Fluorescence Microscopy

Published on: May 22, 2020

10.4K
In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy
06:22

In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy

Published on: July 29, 2019

14.0K

Related Experiment Videos

Last Updated: Aug 30, 2025

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
08:55

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments

Published on: April 24, 2020

3.1K
Three-Dimensional Imaging of the Vertebral Lymphatic Vasculature and Drainage using iDISCO+ and Light Sheet Fluorescence Microscopy
10:05

Three-Dimensional Imaging of the Vertebral Lymphatic Vasculature and Drainage using iDISCO+ and Light Sheet Fluorescence Microscopy

Published on: May 22, 2020

10.4K
In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy
06:22

In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy

Published on: July 29, 2019

14.0K

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Biomedical Engineering

Background:

  • Cerebrospinal fluid (CSF) is essential for nutrient delivery and waste removal in the central nervous system.
  • Disrupted CSF flow is implicated in neurodegenerative diseases (e.g., Alzheimer's) and optic neuropathies (e.g., glaucoma).
  • Understanding CSF dynamics, particularly around the optic nerve, is crucial for diagnosing and treating related disorders.

Purpose of the Study:

  • To provide a comprehensive review of the anatomy and flow pathways of the CSF system.
  • To emphasize the role and dynamics of CSF circulation at the optic nerve.
  • To highlight current imaging technologies and computational modeling approaches for studying CSF flow.

Main Methods:

  • Literature review of anatomical studies, imaging techniques, and computational fluid dynamics models related to CSF.
  • Synthesis of information on CSF pathways, focusing on the optic nerve subarachnoid space.
  • Discussion of advanced imaging modalities (e.g., MRI) and their application in visualizing CSF dynamics.
  • Introduction to computational models used for simulating and predicting CSF flow patterns.

Main Results:

  • Detailed description of CSF anatomy and major circulation routes within the central nervous system.
  • Emphasis on the unique CSF pathways surrounding the optic nerve and their clinical relevance.
  • Overview of imaging technologies capable of visualizing CSF flow and associated anatomical structures.
  • Introduction to the application of computational models in understanding complex CSF dynamics.

Conclusions:

  • The CSF system, especially around the optic nerve, is critical for maintaining neurological and ocular health.
  • Advanced imaging and computational modeling offer powerful tools for investigating CSF dynamics.
  • Further research is needed to fully elucidate CSF circulation mechanisms at the optic nerve and their pathological implications.