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Updated: Aug 30, 2025

Minimally Invasive Thumb-sized Pterional Craniotomy for Surgical Clip Ligation of Unruptured Anterior Circulation Aneurysms
Published on: August 11, 2015
Endovascular selective hypothermia facilitates giant aneurysm clipping: illustrative case
Thomas K Mattingly1,2, Pablo Lopez-Ojeda1, Miguel Arango3
1Departments of Neurosurgery.
Background:
The authors present a case of selective hypothermia used for neuroprotection during clipping of a giant partially thrombosed middle cerebral artery (MCA) aneurysm. Although these cases have traditionally required deep hypothermic cardiac arrest, this case illustrates a novel and entirely endovascular solution that avoids cardiac standstill and whole-body cooling.
Observations:
This is, to the authors' knowledge, the first case in human surgery of a catheter-based selective hypothermic circuit used to facilitate MCA trapping for almost 30 minutes. Core temperatures never dropped below 34°C, and the patient recovered uneventfully and has been well for over 5 years.
Lessons:
The technical nuances and physiological changes unique to selective hypothermia are discussed.
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