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Updated: Aug 30, 2025

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders
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Copper Deficiency in Wilson's Disease with a Normal Zinc Value

Masayuki Ueda1, Kazuto Katsuse1, Toshiyuki Kakumoto1

  • 1Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan.

Internal Medicine (Tokyo, Japan)
|September 1, 2022
PubMed

Copper deficiency (CD) is a rare complication of long-term treatment of Wilson's disease (WD) and is usually accompanied by high serum zinc levels. A 57-year-old woman with WD presented with limb weakness and sensory disturbance due to myeloneuropathy and macrocytic anemia after 36 years of treatment. Markedly reduced serum free copper values confirmed CD, which was considered to be caused by progressive dysphagia and severe diarrhea rather than zinc overdose because of the normal serum zinc levels. Discontinuing copper-reducing therapy and increasing copper intake improved her symptoms. Physicians should be alert for the risk of CD in WD patients, especially those with dysphagia.

Keywords:
Wilson's diseasecopper deficiencydysphagiamacrocytic anemiamyeloneuropathy

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