Pentosan polysulfate regulates hepcidin expression in native Mongolian horses

Area of Science:

• Equine Sports Medicine
• Veterinary Pharmacology

Background:

• Hepcidin is a key regulator of iron metabolism.
• Elevated hepcidin levels can negatively impact athletic performance in horses.
• Pentosan polysulfate (PPS) is used in equine medicine for various conditions.

Purpose of the Study:

• To investigate the anti-hepcidin effect of pentosan polysulfate (PPS) in Mongolian horses.
• To evaluate the impact of PPS on serum hepcidin and iron concentrations before and after racing.

Main Methods:

• Twenty-six healthy Mongolian horses were randomized into two groups: PPS treatment and placebo.
• PPS was administered weekly for four weeks.
• Blood samples were collected at baseline (D0), before race (BR), and after race (AR) for analysis.

Main Results:

• A significant reduction in hepcidin was observed after racing in the PPS group compared to placebo (P<0.05 and P<0.01).
• The difference in hepcidin concentration (D0-BR and BR-AR) was greater in the PPS group than in the placebo group.
• Iron concentration differences were reduced in the PPS group compared to placebo.

Conclusions:

• Pentosan polysulfate (PPS) demonstrates a novel anti-hepcidin effect in horses.
• PPS may offer a therapeutic strategy for controlling hepcidin levels in equine athletes.
• Further molecular studies are warranted to elucidate the mechanisms of PPS action.