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Bordetella pertussis and outer membrane vesicles
Çiğdem Yılmaz Çolak1, Burcu Emine Tefon Öztürk2
1TUBITAK, Marmara Research Center, Life Sciences.
Pathogens and Global Health
|September 1, 2022
Summary
Outer membrane vesicles (OMVs) show promise as a next-generation pertussis vaccine platform against Bordetella pertussis. Further research is needed to address challenges and advance clinical development for improved whooping cough prevention.
Area of Science:
- Bacteriology and Immunology
- Vaccine Development
Background:
- Pertussis (whooping cough), caused by Bordetella pertussis, remains a threat, especially to infants, despite widespread vaccination.
- Resurgence of pertussis is linked to factors including waning immunity and limitations of current vaccines, particularly acellular pertussis vaccines.
Approach:
- This review focuses on outer membrane vesicles (OMVs) as a potential vaccine platform against B. pertussis.
- It examines the composition, isolation, and purification methods of OMVs and their immunogenic properties.
Key Points:
- OMVs from B. pertussis carry essential antigenic structures like toxins and lipopolysaccharides (LPS).
- Preclinical studies in animal models and human subjects demonstrate promising results for OMV-based pertussis vaccines.
- Variability in OMV composition due to different production methods necessitates standardization for vaccine development.
Conclusions:
- OMVs represent an attractive candidate for next-generation pertussis vaccines.
- Continued research is crucial to overcome challenges and advance OMV-based vaccine candidates into clinical trials for effective whooping cough control.
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