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Updated: Aug 30, 2025
Transcutaneous Microcirculatory Imaging in Preterm Neonates
Published on: December 31, 2015
Evaluation of tissue perfusion status in moderate to late preterm
1Department of Neonatology, Children's Hospital of Shanxi and Women Health Center of Shanxi, Affiliate of Shanxi Medical University, Taiyuan City, Shanxi Province, China. yz321yz@21cn.com.
Insights
Tissue perfusion and hemodynamic stability in preterm infants showed increases in heart rate and blood pressure within eight days. However, circadian rhythms for perfusion index and blood pressure were not established by day eight.
Area of Science:
- Neonatal physiology
- Circadian rhythms
- Hemodynamics
Background:
- Moderate to late preterm infants experience significant physiological changes post-birth.
- Understanding tissue perfusion and hemodynamic stability is crucial for neonatal care.
- Circadian rhythms in preterm infants are not well-established in early postnatal life.
Purpose of the Study:
- To investigate tissue perfusion status and circadian rhythm in moderately premature infants.
- To monitor hemodynamic stability indicators including perfusion index (PI), blood pressure (BP), heart rate (HR), respiratory rate (RR), oxygen saturation (SpO2), and body temperature.
- To analyze diurnal variations in these parameters within eight days after birth.
Main Methods:
- Prospective study conducted from July to October 2019.
- Monitoring of hemodynamic parameters (PI, BP, HR, RR, SpO2, temperature) in moderate to late preterm infants.
- Data collected in the morning and at night within eight days post-birth.
Main Results:
- No statistically significant difference in perfusion index (PI) between morning and night.
- Heart rate (HR) and blood pressure (BP) showed a significant increase within the first eight days post-birth.
- Weak positive correlations observed between PI and gestational age, HR, and time; negative correlation with SpO2.
- Blood pressure gradually increased to a stable level by days three to four.
Conclusions:
- Perfusion index and heart rate in moderate to late preterm infants increase within eight days post-birth.
- Blood pressure stabilizes by days three to four after birth.
- Circadian rhythms for tissue perfusion (PI) and blood pressure were not established by day eight in this cohort.
Abstract:
The aim of this study was to investigate the tissue perfusion status and circadian rhythm in moderately premature infants. As a prospective study, from July 2019 to October 2019, the haemodynamic stability of moderate to late preterm, including such indicators as perfusion index (PI), blood pressure (systolic/diastolic) (BP), heart rate (HR), respiratory rate (RR), oxygen saturation (SpO2) and body temperature were monitored in the morning and at night within eight days after birth. There was no difference of statistical significance between PI values in the morning and at night (P>0.05). The HR from days six to eight after birth was higher than days one to three (P<0.05). The HR increased significantly on days seven and eight compared with days four and five (P<0.05). The BP from days three to eight was significantly higher than on day one (P<0.05), and the BP from days four to eight was higher than on day two. There was a weak positive correlation between the PI values and gestational age (GA) (r=0.097), HR (r=0.067) and time (r=0.284), and a negative correlation with SpO2 (r=-0.113). The PI and HR of moderate to late preterm increased within eight days after birth. BP was relatively lower after birth and gradually increased to a stable level on days three to four. The PI and BP circadian rhythms associated with tissue perfusion were not established on day eight after birth.
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