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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
Delivery process and effective design of vectors for cancer therapy
Fengyuan Gao1, Bing Yu1,2, Hailin Cong1,2
1Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao 266071, China. yubingqdu@yahoo.com.
Abstract:
In recent years, the efficacy of nano-drugs has not been significantly better than that of the drugs themselves, mainly because nano-drugs enter the tumor vasculature, stay near the blood vessels, and cannot enter the tumor tissues or tumor cells to complete the drug delivery process. Although intratumor injection can significantly decrease this risk, the side effects are strong. The advent of drug delivery carrier materials offers an opportunity to avoid the side effects of systemic drug delivery and the damage caused by tumor resection, holding great promise for the future of cancer therapy. Here, we systematically review recent research advances in the classification of drug delivery carrier materials and the delivery process in drug delivery systems. This review is divided into several main sections, first, we summarize the classification of tumor drug carrier materials, including drug delivery vectors and gene delivery vectors, etc., which are introduced in detail, respectively. Then we describe the carrier materials to deliver the drug cascade and the transition pathways for drug delivery, including stabilization transitions, charge inversions, and size changes. Finally, we discuss the current design strategies and research progress of drug vectors and provide a summary and outlook. This review aims to summarize different drug delivery vehicles and delivery processes to provide ideas for effective cancer therapy.
Insights
Novel drug delivery carriers overcome nano-drug limitations in cancer therapy. These materials improve tumor targeting and drug release, offering a promising alternative to traditional treatments and reducing side effects.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Nano-drug efficacy is limited by poor tumor tissue penetration.
- Intratumoral injection causes severe side effects.
- Drug delivery carriers offer a solution to systemic toxicity and surgical damage.
Purpose of the Study:
- To systematically review advancements in drug delivery carrier materials for cancer therapy.
- To classify tumor drug carrier materials and delivery processes.
- To discuss design strategies and future outlook for drug vectors.
Main Methods:
- Review of recent research on drug delivery carrier materials.
- Classification of drug delivery vectors and gene delivery vectors.
- Analysis of carrier material transition pathways (stabilization, charge inversion, size change).
Main Results:
- Nano-drugs often fail to reach tumor cells due to vascular confinement.
- Drug delivery carriers can be classified into drug and gene delivery vectors.
- Transition pathways like charge inversion and size changes facilitate drug release.
Conclusions:
- Drug delivery carriers hold significant promise for improving cancer therapy efficacy.
- Understanding carrier material classifications and delivery processes is crucial for effective cancer treatment.
- Further research into design strategies can optimize drug vector performance.
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