Related Experiment Video

Updated: Aug 30, 2025

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
11:32

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

Published on: February 23, 2014

15.2K

[Survival in pediatric patients with pneumonia in coronavirus disease 2019]

Efrén Murillo-Zamora1, Alicia Jiménez-Álvarez2

  • 1Instituto Mexicano del Seguro Social, Unidad de Medicina Familiar No. 19, Departamento de Epidemiología. Colima, Colima, México.

Revista Medica Del Instituto Mexicano Del Seguro Social
|September 1, 2022
PubMed

Insights

Children and adolescents with COVID-19 pneumonia face survival challenges. Immunosuppression history significantly increases the risk of fatal outcomes in these young patients.

Area of Science:

  • Pediatric Infectious Diseases
  • Epidemiology
  • Critical Care Medicine

Background:

  • Limited evidence exists on prognostic factors for coronavirus disease 2019 (COVID-19) pneumonia in children and adolescents.
  • Pneumonia is a significant complication of COVID-19 in pediatric populations.

Purpose of the Study:

  • To determine the survival rates of hospitalized children and adolescents with COVID-19 related pneumonia.
  • To identify prognostic factors associated with adverse outcomes in this cohort.

Main Methods:

  • A cohort study was conducted in Mexico analyzing data from hospitalized pediatric patients with COVID-19 pneumonia.
  • Kaplan-Meier survival analysis and Cox proportional-hazards regression were employed to assess survival functions and risk factors.

Main Results:

  • The study included 1423 patients with a mortality rate of 13.7 per 1000 person-days.
  • Overall survival at the end of hospital stay was 69.3%.
  • History of immunosuppression was a significant risk factor for fatal outcomes (Hazard Ratio = 2.70).

Conclusions:

  • This study provides a comprehensive characterization of survival in a large cohort of pediatric patients with COVID-19 pneumonia.
  • Minors with a history of immunosuppression and pneumonia face a substantially increased risk of mortality.
Abstract

Keywords:
AdolescentChildCoronavirus InfectionsPneumoniaSurvival Analysis

More Related Videos

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii09:17

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

Published on: January 2, 2017

14.8K
Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia04:32

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia

Published on: June 28, 2018

12.0K

Related Concept Videos

Pneumonia IV: Management01:28

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
433
Pneumonia V: Nursing management and Prevention01:30

Pneumonia V: Nursing management and Prevention

Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
2.4K
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
402
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
310
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
445
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
328