Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing CellaVision peripheral blood and advanced RBC application software's impact on hematologic morphology reporting: Real-world implementation experience in a large Veterans Affairs hospital.

American journal of clinical pathology·2024
Same author

Evaluating the Sysmex DI-60 Integrated Slide Processing System's impact on hematology differential turnaround times and patient care: Real-world implementation experience in a large Veterans Affairs hospital.

American journal of clinical pathology·2024
See all related articles

Related Experiment Video

Updated: Aug 30, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

1.8K

Implementing Reticulocyte Hemoglobin Into Current Hematology Algorithms.

Cory R Lundgren1

  • 1Department of Clinical Laboratory Science, University of Kansas Medical Center, Kansas City, KS, USA.

American Journal of Clinical Pathology
|September 1, 2022
PubMed
Summary
This summary is machine-generated.

Reticulocyte hemoglobin is a promising tool for screening iron deficiency and iron-deficiency anemia. This biomarker offers high sensitivity and specificity, potentially simplifying diagnostic processes.

Keywords:
Iron deficiencyIron-deficiency anemiaReticulocyte hemoglobinSensitivitySpecificity

More Related Videos

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management
05:35

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management

Published on: January 19, 2024

897
Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
11:59

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Published on: September 6, 2017

7.4K

Related Experiment Videos

Last Updated: Aug 30, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

1.8K
Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management
05:35

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management

Published on: January 19, 2024

897
Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
11:59

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Published on: September 6, 2017

7.4K

Area of Science:

  • Hematology
  • Clinical Diagnostics
  • Biomarker Research

Background:

  • Iron deficiency anemia (IDA) diagnosis relies on various biomarkers.
  • Reticulocyte hemoglobin (Ret-He) is explored as a potential screening tool.
  • Comorbidities can complicate traditional iron deficiency screening.

Approach:

  • Systematic review and meta-analysis of 14 studies (2015-2022).
  • Analyzed hemoglobin, reticulocyte hemoglobin, and mean cell volume (MCV).
  • Calculated sensitivity, specificity, and AUC for Ret-He in diagnosing iron deficiency and IDA.

Key Points:

  • Reticulocyte hemoglobin values showed significant variation between studies, unlike hemoglobin and MCV.
  • Ret-He ranges effectively differentiate controls, iron deficiency, and IDA.
  • Ret-He < 26 pg indicates IDA; 26-31.5 pg suggests iron deficiency, with AUC 0.889.

Conclusions:

  • Reticulocyte hemoglobin demonstrates high sensitivity (92.3-100%) and specificity (71.4-100%) for iron deficiency and IDA.
  • Ret-He shows potential as a rapid screening test for iron deficiency and IDA.
  • This biomarker may offer a more efficient diagnostic pathway.