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Updated: Aug 30, 2025
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
S100A10 might be a novel prognostic biomarker for head and neck squamous cell carcinoma based on bioinformatics
Shuo Gao1, Hao Zhang1, Linbin Lai1
1Lab for Bone Metabolism, Xi'an Key Laboratory of Special Medicine and Health Engineering, Key Lab for Space Biosciences and Biotechnology, Research Center for Special Medicine and Health Systems Engineering, NPU-UAB Joint Laboratory for Bone Metabolism, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi, China.
Abstract:
Head and neck squamous cell carcinoma (HNSCC) is a frequent malignant tumor of the head and neck with a dismal survival probability due to relapse and metastasis. S100As have been identified as being involved in the tumor procession of various cancer types. However, the expressions of S100As in HNSCC and their prognostic relevance are unknown. Bioinfromatics analysis was conducted to identify the prognostic value and function of S100As in HNSCC patients. In the study, we found that high mRNA expression levels of S100A3, S100A4, S100A7A, S100A9, and low mRNA expression levels of S100A1, S100A10 were related with a good overall survival in HNSCC patients. Importantly, the prognosis model suggested that S100A10 may have a certain impact on the development of HNSCC. Moreover, single-cell RNA sequencing analysis clarified that the specific functions of S100A10 had positive regulatory effects on metastasis, blood vessel generation, EMT, hypoxia, and invasion. Our findings implied that S100A10 might be a new prognostic biomarker for HNSCC, and played a role in promoting the occurrence, and development of HNSCC.
