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Artificial Microvesicles: New Perspective on Healing Tendon Wounds.

Elena Zakirova1, Alexander Aimaletdinov1, Milana Mansurova1

  • 1Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russian Federation.

Cells, Tissues, Organs
|September 1, 2022
PubMed
Summary

Artificially derived microvesicles (MVs) from horse stem cells promote tendon healing. These MVs stimulated cell growth and collagen production in damaged rat tendons, showing promise for future clinical applications in tendon repair.

Keywords:
DifferentiationMembrane fusionMicrovesicleStem/progenitor cellTendon

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Area of Science:

  • Regenerative Medicine
  • Biotechnology
  • Veterinary Science

Background:

  • Tendons have limited natural repair capacity, leading to functional deficits.
  • Current cell therapies for tendon repair face challenges like ectopic bone formation.
  • Microvesicles (MVs) from stem cells (SCs) are a promising alternative for regenerative therapies.

Purpose of the Study:

  • To characterize artificially derived MVs from equine mesenchymal stem cells (MSCs).
  • To assess the effects of these MVs on rat tendon cells in vitro and damaged tendons in vivo.
  • To evaluate the potential of MVs for stimulating tendon regeneration.

Main Methods:

  • Extraction and characterization of MVs from equine MSCs.
  • Isolation and characterization of rat tendon stem/progenitor cells (TSCs).
  • In vitro co-cultivation of TSCs with MVs and in vivo administration to damaged rat tendons.

Main Results:

  • Equine MVs fused with rat TSCs without toxicity.
  • MVs stimulated TSC proliferation, migration, and increased VEGF and fractalkine expression.
  • In vivo studies showed accelerated tendon regeneration and increased collagen I and III synthesis.

Conclusions:

  • Artificially derived MVs exhibit regeneration-stimulating effects in vitro and in vivo.
  • Cross-species MV fusion is possible, opening avenues for novel therapeutic strategies.
  • These findings represent a significant step toward clinical applications of MVs for tendon repair.