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Updated: Aug 30, 2025
11:49
Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application
Published on: March 8, 2019
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DETERMINATION OF FACTORS ASSOCIATED WITH LONG-TERM ENDOTHELIAL LOSS AND REFRACTIVE RESULT IN PATIENTS WITH ARTISAN
Summary
Phakic Artisan lenses offer good refractive outcomes for myopia but show significant long-term endothelial cell loss in many patients. Close monitoring of endothelial cell density post-surgery is crucial.
Area of Science:
- Ophthalmology
- Biomedical Engineering
- Cell Biology
Background:
- Phakic intraocular lenses (PIOLs) are used for refractive error correction.
- Iris-claw PIOLs, such as the Artisan lens, are an option for myopia and myopic astigmatism.
- Long-term outcomes and potential complications require thorough investigation.
Purpose of the Study:
- To evaluate changes in endothelial cell density (ECD) in patients with Artisan PIOLs.
- To assess refractive results and identify risk factors for endothelial loss.
- To determine the long-term safety and efficacy of Artisan lenses for myopia.
Main Methods:
- Retrospective analysis of a database of patients with Artisan PIOLs (1998-2011).
- Inclusion of eyes with at least 5 years of follow-up.
- Analysis of ECD changes and correlation with potential associated factors.
Main Results:
- Over 11.9 years, 43.8% of eyes experienced >25% endothelial cell loss.
- 47.0% of eyes showed an annual loss >1.6%.
- 51% had final ECD <2000 cells/mm², with 8.8% <1000 cells/mm²; no significant risk factors identified. 10% of lenses were explanted.
Conclusions:
- Artisan phakic lenses provide predictable long-term refractive results for high myopia.
- A significant percentage of patients experience long-term endothelial cell loss.
- Strict postoperative monitoring, including ECD evaluation, is essential; further research is needed.
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