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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Fractures: Bone Repair01:27

Fractures: Bone Repair

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Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
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Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
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Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
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Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population
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Risk assessment tools for osteoporosis and fractures in 2022.

John J Carey1, Paulo Chih-Hsing Wu2, Diane Bergin3

  • 1National University of Ireland Galway, 1007, Clinical Sciences Institute, Galway, H91 V4AY, Ireland.

Best Practice & Research. Clinical Rheumatology
|September 1, 2022
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Summary

Osteoporosis affects millions globally, causing fragility fractures. Current risk assessment tools are evolving, with future approaches prioritizing personalized strategies for better patient outcomes.

Keywords:
DiagnosisFracture riskOsteoporosisOsteoporosis riskPrognosis

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Area of Science:

  • Endocrinology
  • Geriatrics
  • Public Health

Background:

  • Osteoporosis is a prevalent non-communicable disease, leading to significant morbidity, mortality, and healthcare costs due to fragility fractures.
  • The World Health Organization has long focused on understanding and assessing osteoporosis risk, particularly in postmenopausal women.
  • Current risk assessment tools, while improving, often employ a 'one-size-fits-all' approach with limitations in specificity.

Purpose of the Study:

  • To review the current landscape of osteoporosis risk assessment and screening methodologies.
  • To identify areas of uncertainty and propose future developments in osteoporosis risk evaluation.
  • To emphasize the need for a more personalized approach to osteoporosis risk assessment and management.

Main Methods:

  • Review of existing literature and clinical practices for osteoporosis risk assessment.
  • Analysis of traditional and modern tools for identifying individuals at risk of osteoporosis and fractures.
  • Discussion of emerging technologies such as artificial intelligence and big data science in risk prediction.

Main Results:

  • Dual-energy X-ray absorptiometry (DXA) remains a primary tool, but other methods are available for fracture risk assessment.
  • Numerous risk assessment tools exist, with ongoing advancements aiming for greater accuracy and personalization.
  • Future directions point towards integrating advanced technologies for more precise individual risk stratification.

Conclusions:

  • Optimizing the use of risk assessment tools requires understanding their specific applications for different patients and purposes.
  • A comprehensive approach to screening and assessing fracture risk is crucial for reducing the global burden of osteoporosis.
  • Personalized risk assessment, leveraging modern technologies, holds the key to more effective osteoporosis management.