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Related Concept Videos

Olfaction01:25

Olfaction

44.8K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
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Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

9.5K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
9.5K
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

9.2K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
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Related Experiment Video

Updated: Aug 30, 2025

Quadruple Immunostaining of the Olfactory Bulb for Visualization of Olfactory Sensory Axon Molecular Identity Codes
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Quadruple Immunostaining of the Olfactory Bulb for Visualization of Olfactory Sensory Axon Molecular Identity Codes

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Decoding the olfactory map through targeted transcriptomics links murine olfactory receptors to glomeruli.

Kevin W Zhu1, Shawn D Burton2,3, Maira H Nagai1

  • 1Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, 27710, USA.

Nature Communications
|September 1, 2022
PubMed
Summary
This summary is machine-generated.

Researchers mapped olfactory receptors (ORs) in the mouse olfactory bulb using advanced spatial transcriptomics. This study successfully mapped 86% of ORs, revealing a link between OR sequence and their precise location within the olfactory bulb.

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Perforated Patch-clamp Recording of Mouse Olfactory Sensory Neurons in Intact Neuroepithelium: Functional Analysis of Neurons Expressing an Identified Odorant Receptor
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Related Experiment Videos

Last Updated: Aug 30, 2025

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Perforated Patch-clamp Recording of Mouse Olfactory Sensory Neurons in Intact Neuroepithelium: Functional Analysis of Neurons Expressing an Identified Odorant Receptor
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Perforated Patch-clamp Recording of Mouse Olfactory Sensory Neurons in Intact Neuroepithelium: Functional Analysis of Neurons Expressing an Identified Odorant Receptor

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Recording Temperature-induced Neuronal Activity through Monitoring Calcium Changes in the Olfactory Bulb of Xenopus laevis
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Area of Science:

  • Neuroscience
  • Genomics
  • Molecular Biology

Background:

  • Olfactory sensory processing relies on the precise organization of olfactory receptors (ORs) within olfactory bulb glomeruli.
  • Mapping ORs to glomeruli is crucial for understanding olfactory system function.
  • Previous high-throughput methods were limited by low-abundance OR expression in mouse glomeruli.

Purpose of the Study:

  • To develop and apply a high-throughput method for mapping olfactory receptors to glomeruli in the mouse olfactory bulb.
  • To overcome challenges posed by low-abundance olfactory receptor expression.
  • To investigate the relationship between olfactory receptor sequence and glomerular position.

Main Methods:

  • Combined sequential sectioning along anteroposterior, dorsoventral, and mediolateral axes.
  • Utilized target capture enrichment sequencing to enhance detection of low-abundance transcripts.
  • Applied spatial transcriptomics to analyze tissue sections.

Main Results:

  • Successfully mapped the spatial location of 86% of olfactory receptors across the mouse olfactory bulb.
  • Overcame limitations of low-abundance olfactory receptor expression.
  • Discovered a correlation between olfactory receptor sequence and glomerular position.

Conclusions:

  • The developed method enables comprehensive high-throughput mapping of olfactory receptors in the mouse.
  • This spatial mapping provides critical insights into the organization of the olfactory system.
  • A relationship between olfactory receptor sequence and glomerular topography was identified, advancing our understanding of olfactory coding.