Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Biocompatible designated Resin-3D-printed polymers exhibit reproductive toxicity prevented by Parylene-C.

bioRxiv : the preprint server for biology·2026

Same author

Hormone-dependent mitochondrial resilience in leiomyoma cells exposed to oxidative stress.

Endocrinology·2026

Same author

Microglial fructose metabolism is essential for glioblastoma growth.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

Production and Use of Customizable Agarose Molds for Scaffold-Free Mouse Ovarian Follicle Culture.

Journal of visualized experiments : JoVE·2025

Same author

Uterine <i>Pgrmc2</i> Deficiency Attenuates Endometrial Hyperplasia and Cancer and Prolongs Lifespan in a <i>Pten</i> Loss-of-Function-Induced Cancer Model.

Cancers·2025

Same author

Somatic <i>MED12</i> Mutations in Myometrial Cells.

Cells·2024

Search research articles

Related Experiment Video

Updated: Aug 30, 2025

Establishing a Mouse Model of Thin Endometrium

Establishing a Mouse Model of Thin Endometrium

Published on: November 1, 2024

Strategies for modelling endometrial diseases.

Alina R Murphy¹, Hannes Campo¹, J Julie Kim²

¹Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Northwestern University, Chicago, IL, USA.

Nature Reviews. Endocrinology

|September 1, 2022

Summary

New organoid models offer a powerful way to study complex endometrial diseases like endometriosis and adenomyosis. These advanced in vitro systems are crucial for understanding and developing treatments for these conditions.

More Related Videos

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice

Published on: November 24, 2020

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility

Published on: April 5, 2024

Related Experiment Videos

Last Updated: Aug 30, 2025

Establishing a Mouse Model of Thin Endometrium

Establishing a Mouse Model of Thin Endometrium

Published on: November 1, 2024

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice

Published on: November 24, 2020

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility

Published on: April 5, 2024

Area of Science:

Reproductive Biology
Gynecology
Biomedical Engineering

Background:

The endometrium undergoes monthly hormonal changes for pregnancy, but diseases like endometriosis and endometrial cancer lack effective treatments.
Understanding endometrial complexity and hormonal influences across the menstrual cycle is challenging.
Current research needs better in vitro models that mimic endometrial structure and function.

Purpose of the Study:

To review novel organoid and microfluidic models for studying endometrial diseases.
To highlight advancements in in vitro modeling of the human endometrium.
To provide a reference for researchers in endometrial biology and disease.

Main Methods:

Organoid technology utilizing human cells to create in vitro endometrial models.
Microfluidic systems designed to mimic the endometrial microenvironment.
Review of emerging technologies for endometrial research.

Main Results:

Organoid technology enables revolutionary in vitro modeling of the endometrium.
New models offer unprecedented insights into endometrial cell behavior and disease.
Microfluidics and organoids represent a new frontier in studying endometrial diseases.

Conclusions:

Emerging organoid and microfluidic models are transforming the study of endometrial diseases.
These advanced models are essential for unraveling the complexity of endometrial disorders.
Further development of these systems promises improved understanding and treatment strategies.