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Current perspective of immunomodulators for lung transplant
Dhruva Sharma1, Ganapathy Subramaniam Krishnan2, Neha Sharma3
1Department of Cardiothoracic and Vascular Surgery, SMS Medical College & Attached Hospitals, J L N Marg, Jaipur, 302001 Rajasthan India.
Indian Journal of Thoracic and Cardiovascular Surgery
|September 2, 2022
Summary
Lung transplantation requires intensive immunosuppression to prevent rejection. This review explores current and novel strategies to improve outcomes for lung transplant recipients, focusing on managing acute and chronic rejection.
Area of Science:
- Cardiology
- Immunology
- Transplant Surgery
Background:
- Lung transplantation is a vital treatment for end-stage lung disease.
- Lung transplants necessitate intensive immunosuppression due to high rejection rates.
- The first modern lung transplant occurred in 1983, with thousands performed since.
Purpose of the Study:
- To review current immunosuppressive strategies for lung transplantation.
- To discuss emerging agents for preventing lung transplant rejection.
- To address both acute and chronic rejection in lung transplant recipients.
Main Methods:
- Literature review of existing immunosuppressive protocols.
- Analysis of recent advancements in immunosuppressive agents.
- Synthesis of data on strategies to combat lung transplant rejection.
Main Results:
- Current immunosuppression protocols aim to balance efficacy and toxicity.
- Emerging agents show promise in improving long-term graft survival.
- Rejection remains a significant challenge in lung transplantation.
Conclusions:
- Optimizing immunosuppression is crucial for lung transplant success.
- Novel agents may offer improved prevention of acute and chronic rejection.
- Continued research is needed to refine lung transplant immunosuppressive strategies.
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